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美國(guó)Mersana Therapeutics
Mersana 是一家未公開(kāi)上市的由風(fēng)險(xiǎn)投資做為后盾 (venture-backed) 的企業(yè)。該公司正在通過(guò)使用 Fleximer(R) 開(kāi)發(fā)基于臨床驗(yàn)證藥物的新型抗腫瘤藥劑。Fleximer(R) 是一種獲得專(zhuān)利的生物可降解與生物惰性物質(zhì)，能增強(qiáng)藥物的藥物代謝動(dòng)力、安全性和溶解性。Mersana 擁有來(lái)自 Massachusetts General Hospital 對(duì)其核心技術(shù)的獨(dú)家授權(quán)。Mersana 研發(fā)的產(chǎn)品系列中包含一些已經(jīng)通過(guò)其專(zhuān)利技術(shù)而得到改進(jìn)的復(fù)方藥，這些復(fù)方藥具有抗多種癌癥的活性，并在人體實(shí)驗(yàn)中得到了證明。Mersana 的投資方包括 Fidelity Biosciences、ProQuest Investments、Rho Ventures、Harris & Harris Group 和 PureTech Ventures。

Fleximer 技術(shù)能通過(guò)把生物降解能力和“生物暗中作用”特性獨(dú)特地結(jié)合起來(lái)，改善可有效用作抗癌藥劑的細(xì)胞毒素復(fù)方藥物的治療指數(shù)，從而使 Fleximer(R) 物質(zhì)與其共軛物體的具有長(zhǎng)的循環(huán)周期且成為非免疫毒素療法 (non-immunotoxic)。Fleximer 分子具有如下特點(diǎn)：可溶于水、在一般的生產(chǎn)過(guò)程和正常生理狀態(tài)下很穩(wěn)定，同時(shí)具有細(xì)胞攝入時(shí)不涉及酶作用的生物降解能力。


Mersana engineers novel drug conjugates that maximize the potential of new and established therapeutic classes. Our technology harnesses the power and synergy of nanotechnology, biologics and small molecules.

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Mersana is advancing its own pipeline of next-generation drugs with best-in-class potential to address unmet needs and improve patient outcomes in multiple oncology indications. Utilizing our technology, we are developing a portfolio of next-generation antibody-drug conjugates (ADC) with superior properties not found with current ADC technologies. Our clinical pipeline consists of two cancer therapeutics with blockbuster potential. XMT-1001 is a potentially best-in-class novel "tecan" conjugate that is currently being investigated in a Phase 1b extension trial in patients with lung cancers. XMT-1107 is a first-in-class anti-angiogenic conjugate with a unique mechanism of action that is currently in a Phase 1 trial in patients with refractory, advanced solid tumors. XMT-1107 was licensed to Teva on a worldwide basis except for Japan, where Mersana elected to retain rights. These clinical candidates reflect the successful application of our unique conjugation system.

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This versatile conjugation system integrates Fleximer?, a clinically validated biodegradable polymer, with a broad array of customized linker chemistries designed to control conjugation, stability and release of diverse classes of therapeutic payloads. This system provides important benefits required for the development of next-generation drugs across therapeutic modalities, including ADCs, antibody fragments, small molecules, biologics and siRNA, as well as synergistic drug combinations. Mersana's approach results in completely novel drugs with intellectual property protection and extended patent life, via novel composition-of-matter.

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Our technology is being leveraged in multiple therapeutic areas through partnerships. Mersana is interested in pursuing technology-enabling and proprietary drug candidate-based opportunities with partners interested in accessing our cutting-edge, clinically validated drug conjugation system.

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