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美國(guó)NobleGen Biosciences  
一家位于馬塞諸塞州的新創(chuàng)公司卓越基因（Noblegen）正在研發(fā)簡(jiǎn)化版納米孔基因組測(cè)序技術(shù)（nanopore genome-sequencing technology）——這項(xiàng)技術(shù)使得平常需要復(fù)雜儀器來(lái)完成的高速廉價(jià)DNA測(cè)序充滿希望。卓越基因公司去年春天建立，它稱自己的技術(shù)能夠直接快速地識(shí)讀DNA序列，使得將測(cè)序技術(shù)帶入臨床檢驗(yàn)科進(jìn)行癌癥和其他疾病的診斷在經(jīng)濟(jì)上變得切實(shí)可行。

卓越基因公司的首席執(zhí)行官弗蘭克·菲絲特（Frank Feist）說(shuō)，公司的目標(biāo)是以每秒50個(gè)堿基的速度進(jìn)行測(cè)序。公司不會(huì)透露其目前樣機(jī)的細(xì)節(jié)，但稱此技術(shù)會(huì)擴(kuò)增至400x400的納米孔陣列，每小時(shí)測(cè)序量超過(guò)5千億堿基（gigabases）——或者15分鐘約30個(gè)人類基因組。


NobleGen Biosciences is building a novel DNA sequencing instrument to enable cost effective personalized medicine, based on highly differentiated IP exclusively licensed from Harvard University and Boston University.

NobleGen’s ‘Optipore’ DNA sequencing platform will be the first to take advantage of a highly effective nanopore-based DNA separation method, which incorporates high-speed optical detection. Low instrument cost and sub micro-liter sample volumes are possible through the use of custom solid-state nanochips, imaged by a simple optical configuration that employs state of the art sCMOS technology, and an off-line chemical DNA conversion process. The Optipore solution enables high accuracy and throughput providing a cost effective solution for whole genome sequencing. Noblegen’s goal is to offer the best cost and performance of any single molecule instrument truly transforming medical prevention, diagnosis and therapy.

Prof. Meller invented the Optipore optical nanopore sequencing technology at Harvard University between 2001 and 2005 and has been developing a prototype sequencer at Boston University since 2006. Prof. Meller has won multiple NIH/NHGRI and NSF awards for Optipore development ($8.3M total). First to publish results obtained from a laboratory prototype demonstrating very accurate, single molecule, multiplex reads of all 4 nucleotide bases from a nanopore array in 5/2010, Prof. Meller has been awarded a $4.2M/ 4 year extension grant in the latest (9/2010) round of NHGRI funding. NobleGen was incorporated in 2/2010 and exclusively licensed the Optipore technology from Harvard University and Boston University in 8/2010. NobleGen has raised seed funding including a highly competitive $200K Launch Award from Boston University.

NobleGen’s headquarters and biochemistry lab are located in Boston, MA.